Breakthrough treatment makes woman third person to be cured of HIV

Breakthrough treatment makes woman third person to be cured of HIV
Breakthrough treatment makes woman third person to be cured of HIV
Westend61/Getty Images

(NEW YORK) — Researchers revealed on Tuesday that an American, described as a middle-aged woman of mixed race, has likely been cured of HIV after undergoing a new transplant procedure using donated umbilical cord blood.

The patient, who needed a stem cell transplant for leukemia, reportedly developed a new HIV-resistant immune system following a breakthrough procedure in which she was genetically matched with umbilical cord stem cells that contained an HIV-resistant mutation.

She was part of a study that began in 2015 designed to monitor outcomes of 25 people with HIV in the U.S. who underwent a transplant, according to the National Institute of Allergy and Infectious Diseases.

Dr. Yvonne Bryson, an infectious disease physician at UCLA, who led the study, discussed their team’s finding along with the patient’s condition at the Conference on Retroviruses and Opportunistic Infections this week.

“Today, we reported the third known case of HIV remission and the first woman following a stem cell transplant and using HIV-resistant cells,” Bryson said in a press conference.

“This case is special for several reasons: First, our participant was a U.S. woman living with HIV of mixed race, who needed a stem cell transplant for treatment of her leukemia. And she would find a more difficult time finding both a genetic match and one with the HIV-resistant mutation to both cure her cancer and potentially her HIV. This is a natural, but rare mutation,” she said.

Bryson added that while this approach of using genetically-matched umbilical cord blood with HIV-resistant mutation opens the door to more diverse populations and studies, she confirmed there is no current routine screening in place in the U.S. for this mutation.

Previously, only two men have been cured of HIV using a bone marrow or stem cell transplant. And while this is the third known case, according to Bryson’s team, of HIV remission in an individual who received a stem cell transplant of any kind, experts in the field caution that this method is not ideal for curing the many millions of HIV-positive people around the globe today.

Bryson said there could eventually be “approximately at least 50 [people] per year that may benefit from this.”

In an interview with Community Health Center, Inc., Dr. Anthony Fauci, the leading expert in infectious disease in the U.S., whose work in HIV care and treatment innovation spans four decades, said, “I don’t want people to think that now this is something that can be applied to the 36 million people [globally] who are living with HIV.”

“This person had an underlying disease that required a stem cell transplant. … It is not practical to think that this is something that’s going to be widely available,” Fauci added. “It’s more of a proof of concept.”

While there is no practical and applicable cure for HIV on a large scale, there have been incredible strides in HIV treatment over the years that allow individuals to live a normal and healthy life.

Known as U=U, or Undetectable=Untransmittable, if an HIV-positive person begins HIV treatment and brings the virus in their body to an undetectable level, the individual cannot transmit the virus to someone as long as they remain on said treatment or medication.

Last month, the U.S. Food and Drug Administration approved the first long-acting injectable drug for HIV prevention.

Until recently, the only medications licensed and approved by the FDA for HIV prevention or pre-exposure prophylaxis, most commonly known as PrEP, were daily pills, which slow the progression of an HIV infection in the body.

PrEP is usually taken daily so that it builds up in in a person’s system, to the point that if there is an HIV infection, it prevents the virus from replicating and spreading throughout the body.

When taken as prescribed, PrEP services reduce the risk of getting HIV from sex by about 99%, according to new data from the Centers for Disease Control and Prevention. Now, individuals who feel at-risk of HIV infection have the option of taking the daily pill, or the new shot every two months, after two initiation injections administered one month apart.

On the vaccine front, Moderna recently announced that it’s launched early stage clinical trials of an HIV mRNA vaccine. ABC News previously reported that the biotechnology company teamed up with the nonprofit International AIDS Vaccine Initiative to develop the shot, which uses the same technology as Moderna’s successful COVID-19 vaccine.

Because bone marrow transplantation is a dangerous and risky procedure, it is considered unethical to perform on people with HIV, unless the person also has cancer and needs a transplant as part of their treatment.

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Cruz, other GOP senators oppose no-fly list for convicted unruly passengers

Cruz, other GOP senators oppose no-fly list for convicted unruly passengers
Cruz, other GOP senators oppose no-fly list for convicted unruly passengers
EllenMoran/Getty Images

(WASHINGTON) — A group of Republican senators sent a letter to the Justice Department on Tuesday to express “strong opposition” to creating a federal no-fly list for unruly passengers, claiming “the majority of recent infractions on airplanes has been in relation to the mask mandate.”

Sens. Mike Lee of Utah, Marco Rubio and Rick Scott of Florida and Ted Cruz of Texas were among those who signed a letter opposing Delta Airlines’ CEO Ed Bastian’s request earlier this month that the DOJ create a “no-fly” list for passengers convicted of federal offenses relating to on-board disruptions.

Last year saw a major spike in unruly passengers, with more than 5,981 reported cases, according to the Federal Aviation Administration. The agency notes, of those cases, 4,290 were mask-related.

“Creating a federal ‘no-fly’ list for unruly passengers who are skeptical of this mandate would seemingly equate them to terrorists who seek to actively take the lives of Americans and perpetrate attacks on the homeland,” the GOP senators’ letter said. “The [Transportation Security Administration] was created in the wake of 9/11 to protect Americans from future horrific attacks, not to regulate human behavior onboard flights.”

The senators argued airlines could create their own no-fly lists and refuse services to unruly passengers, but that it would be an overreach for the federal government to do so.

Many airlines have already done this, but they do not prevent an offender from boarding another carrier. Delta has previously asked other U.S. airlines to share their internal no-fly lists so that people who endangered their crew can’t do so on another airline.

“The creation of this list by DOJ would result in a severe restriction on the ability of citizens to fully exercise their constitutional right to engage in interstate transportation,” the GOP letter said. “It also raises serious concerns about future unrelated uses and potential expansions of the list based on political pressures.”

In Bastian’s request to the DOJ, he indicated that he believes banning unruly passengers from all commercial flights will send a strong signal to the flying public that not following crew member instructions comes with severe consequences.

“This action will help prevent future incidents and serve as a strong symbol of the consequences of not complying with crew member instructions on commercial aircraft,” he wrote.

Unruly passenger incidents onboard Delta planes have increased nearly 100% since 2019, according to Bastian. The airline has placed almost 2,000 people on Delta’s internal no-fly list for refusing to wear a mask and has submitted around 1,000 banned names to the TSA to pursue civil penalties.

Other people in the industry have called for support of a no-fly list for unruly passengers. Sara Nelson, president of the Association of Flight Attendants-CWA, responded in a statement to the GOP senators.

“We’ve been punched, kicked, spit on, and sexually assaulted. This puts everyone at risk and disrupts the safety of flight, which is never acceptable and every single one of the senators who signed this letter knows full well what is at stake if we leave a gap in aviation safety and security,” Nelson said. “It is irresponsible and political brinkmanship that will put our economic security at risk right along with our lives.”

Nelson pushed back against the lawmakers’ argument about mask mandates, noting many charges stem from incidents unrelated to mask-wearing.

“Our union continues to call for the creation of a centralized list of passengers who may not fly for a period of time after being fined or convicted of a serious incident. This is not about ‘masks,’ and the worst attacks have nothing to do with masks,” Nelson said. “You’re either for protecting crew and passengers from these attacks or you’re against. We need clear and consistent rules with strict consequences for those who cannot respect our collective efforts to keep everyone safe – in the air and on the ground.”

Joe DePete, the president of the Air Line Pilots Association, called for the Department of Homeland Security to create a “no-fly list” for unruly passengers.

“There should be zero tolerance for airline passengers who threaten the safety of others,” DePete said in a tweet Tuesday.

Delta responded to the Republican senators in a statement, saying unruly passengers risk the safety of airline staff and other passengers.

“Delta welcomes the interest from Congress as U.S. airlines continue to grapple with an uptick in unruly passengers, putting the safety of airline employees and the flying public at risk,” a spokesperson for Delta told ABC News on Tuesday. “At Delta, nothing is more important than ensuring a safe and secure travel experience for our customers and our people.”

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Some Russian troops moved to firing positions near Ukraine, Putin said be ready by Feb. 16: Sources

Some Russian troops moved to firing positions near Ukraine, Putin said be ready by Feb. 16: Sources
Some Russian troops moved to firing positions near Ukraine, Putin said be ready by Feb. 16: Sources
Alexei NikolskyTASS via Getty Images

(NEW YORK) — While Russia’s defense ministry said Tuesday that some forces would pull back from Ukraine’s borders after completing military exercises, the U.S. has so far not seen that, President Joe Biden said in an address to the nation.

But worrying U.S. officials, Russians troops are instead moving forward closer to the line, including with medical supplies, and being put into firing positions, sources told ABC News.

The U.S. believes that Russia now has all the necessary pieces in place, including 150,000 troops in the region, to launch a swift and brutal invasion of Ukraine, the sources added — the reason why Biden administration officials have now publicly been saying Russia could move “at any time.”

In particular, ABC News has learned that Russian leader Vladimir Putin had told his military forces to be ready to go by Wednesday, Feb. 16, but it is still unclear whether he has made a decision to attack his neighbor.

The Russian government has denied any plans to invade Ukraine and repeatedly accused the U.S. of “hysteria” with these increasingly urgent warnings about one.

“After Russian troops finish drills and return to barracks, the West will declare ‘diplomatic victory’ by having ‘secured’ Russian ‘de-escalation’ — a predictable scenario and cheap domestic political points,” Russian Foreign Minister Sergei Lavrov said Saturday, according to the country’s foreign ministry.

The U.S. believes an invasion would likely begin with electronic warfare and aerial bombardment against critical infrastructure, the sources said, followed by special operations forces entering Kyiv to decapitate the Ukrainian government and resupplying troops entering from Belarus — with plans to complete their operations in 24 to 72 hours.

During his remarks Tuesday, Biden confirmed that Russian troops “remain very much in a threatening position” — warning that an invasion remains “distinctly possible” and would inflict an “enormous” human toll.

But Biden said the U.S. would welcome Moscow pulling back its forces and engaging in diplomatic talks on U.S. and NATO proposals, on issues like arms control and transparency over military exercises.

While Lavrov said Moscow’s response to those proposals would be transmitted in the coming days, Putin said that Russia’s key demands were being ignored — that Ukraine be barred from joining NATO and that the Western military alliance pull back its forces from Eastern European member states.

The U.S. and NATO have said those are nonstarters — issues that only the alliance itself or individual countries can decide and not under Russian pressure.

“This is about more than just Russia and Ukraine. It’s about standing for what we believe in, for the future that we want for our world, for liberty — for liberty, the right of countless countries to choose their own destiny, and the right of people to determine their own futures, or the principle that a country can’t change its neighbor’s borders by force,” Biden said at the White House.

Biden and Putin spoke Saturday — their first conversation in over a month — while their top diplomats Lavrov and Secretary of State Antony Blinken have spoken twice now in recent days. While the door to continued dialogue remains open, both sides have indicated, there are concerns Russia may resort to war even as it negotiates.

Russia already seized Ukrainian territory when it annexed Crimea in 2014, and since then, it has fomented a war against Ukrainian troops by arming and financing separatists in Ukraine’s eastern provinces known as Donbas. Russian parliament passed a resolution Tuesday calling on Putin to recognize them as independent republics — something Putin indicated he would not yet do.

But sources said if Russia attacks Ukraine, it would likely not be against a small slice of territory in Donbas, but a bloody, brutal and swift campaign to topple President Volodymyr Zelenskyy’s administration and install a puppet government.

Amid the heightened U.S. fears, the U.S. has also been concerned that Zelenskyy’s government hasn’t responded quickly enough and isn’t better prepared for a potential Russian invasion, sources said, including the positioning of its forces in eastern Ukraine.

U.S. officials have been urging better preparedness for two months now, the sources added, but President Zelenskyy and his inner circle have been both intent on staving off a panic and persistent in a belief that Moscow wouldn’t invade.

While some U.S. officials doubt Putin is bluffing given the costs, financial and political, of the buildup, many analysts have been skeptical of dire U.S. assessments — with some saying Putin is achieving his ultimate objective: destabilizing an increasingly democratic Ukraine aligned with the West.

“Putin has the hard experience of humiliation in Chechnya that tells him that while Russia might eventually be able to conquer Ukraine, they can’t hold it, and with any crossing of the border they will pay a very high price in blood and treasure,” said retired Col. Stephen Ganyard, a former senior State Department official and now an ABC News contributor. “If he fails in Ukraine, it could be his rule that ends as well.”

In particular, Ganyard said, a Russian invasion is still facing warm, wet weather conditions that make tank movements and aerial bombardment difficult, while the number of massed Russian troops still pales compared to Ukraine’s forces, especially if Russian troops have to occupy a country the size of Texas.

Biden made clear the U.S. still hopes for a diplomatic off-ramp and for Putin to decide against invasion, even as they continue to make preparations for one — from increased military aid for Ukraine, to coordination with European allies and others on sanctions.

Since Russia’s buildup began, allies and partners have come together quickly to prepare a year’s worth of sanctions work in the last six weeks, sources said, including export controls that could devastate Russia’s economy.

But the U.S. is concerned that Russia could maintain its troop buildup and other ways of pressuring Ukraine short of taking military action — and that that could start to splinter the Western coalition’s unity.

Biden made reference to the economic pain that could be felt at home in the U.S., including elevated energy prices because of Russia’s major role as an oil and gas exporter.

“But the American people understand that defending democracy and liberty is never without cost,” Biden said — adding his administration was taking “active steps to alleviate the pressure on our own energy markets.”

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J.J. Abrams teases fourth ‘Star Trek’ film

J.J. Abrams teases fourth ‘Star Trek’ film
J.J. Abrams teases fourth ‘Star Trek’ film
Gareth Cattermole/Getty Images for Paramount Pictures

J.J. Abrams has announced plans for a fourth Star Trek film, ideally with the cast from his 2009 reboot, according to Variety.

“We are thrilled to say that we are hard at work on a new Star Trek film that will be shooting by the end of the year that will be featuring our original cast and some new characters that I think are going to be really fun and exciting and help take Star Trek into areas that you’ve just never seen before,” Abrams revealed at the Paramount Investors Day presentation Tuesday.

“We’re thrilled about this film, we have a bunch of other stories that we’re talking about that we think will be really exciting, so can’t wait for you to see what we’re cooking up. But until then, live long and prosper,” he added.

There’s just one little hitch, though: the studio has yet to enter negotiations with any of original stars, which include Chris Pine as Captain Kirk, Zachary Quinto as Spock, Zoe Saldana as Uhura, John Cho as Sulu, Karl Urban as Bones and Simon Pegg as Scotty. Anton Yelchin, who played Chekhov in Abrams’ previous three movies, died in 2016.

Plans to bring back the cast have been percolating for years, including a 2018 sequel teaming Pine with Kirk’s late father, portrayed in the 2009 film by Chris Hemsworth. The plan ultimately fizzled, reportedly because Paramount couldn’t reach a deal with Pine and Hemsworth. Quentin Tarantino was even circling a project at one time.

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KISS announces plans for 2022 KISS Kruise, expected to feature band’s final “on board” performance

KISS announces plans for 2022 KISS Kruise, expected to feature band’s final “on board” performance
KISS announces plans for 2022 KISS Kruise, expected to feature band’s final “on board” performance
Kevin Mazur/Getty Images

KISS has announced plans for the 11th annual installment of The KISS Kruise, which will take place October 29 to November 3 this fall. According to a message on the seagoing rock festival’s official website, this year’s cruise will be the last time that the band “will perform on the high seas.”

The five-day nautical extravaganza will be the first KISS Kruise to set sail from and visit sites on the West Coast, embarking from Los Angeles and stopping at Cabo San Lucas and Ensenada, Mexico, before returning to port.

You can sign up today at TheKISSKruise.com to have access to a pre-sale for the cruise. The KISS Kruise XI “Experience” will feature an unmasked concert by the band on deck, a full “masked” electric show in the ship’s Stardust Theater, an engraved commemorative gift, two activities with KISS, two activities with individual members of the group, an expo offering rare memorabilia, concerts by various other artists, autograph sessions with members of the cruise’s support acts, and more.

The lineup of acts joining KISS on the cruise is expected to be announced soon.

KISS frontman Paul Stanley appears in a video promoting this year’s KISS Kruise that been posted on the group’s YouTube channel.

“[W]e’re gonna have great bands. We’re gonna have a great time,” Stanley says in the clip, then teases, “Everybody says, ‘When is it gonna be the last one?’ Well, this is KISS Kruise XI, and you don’t want to miss it for a whole lot of reasons. I want you there. You deserve to be there. Be there!”

Meanwhile, KISS’ End of the Road farewell tour is scheduled to relaunch with a South American leg starting April 20 in Santiago, Chile. The trek likely will continue into 2023.

Copyright © 2022, ABC Audio. All rights reserved.

J.J Abrams teases new Star Trek film with original cast

J.J. Abrams teases fourth ‘Star Trek’ film
J.J. Abrams teases fourth ‘Star Trek’ film
Gareth Cattermole/Getty Images for Paramount Pictures

J.J. Abrams has announced plans for a fourth Star Trek film, ideally with the cast from his 2009 reboot, according to Variety.

“We are thrilled to say that we are hard at work on a new Star Trek film that will be shooting by the end of the year that will be featuring our original cast and some new characters that I think are going to be really fun and exciting and help take Star Trek into areas that you’ve just never seen before,” Abrams revealed at the Paramount Investors Day presentation.

“We’re thrilled about this film, we have a bunch of other stories that we’re talking about that we think will be really exciting, so can’t wait for you to see what we’re cooking up. But until then, live long and prosper,” he added.

There’s just one little hitch though: the studio has yet to enter negotiations with any of original stars, which include Chris Pine as Captain Kirk, Zachary Quinto as Spock, Zoe Saldana as Uhura, John Cho as Sulu, Karl Urban as Bones and Simon Pegg as Scotty.

Anton Yelchin, who played Chekhov in Abrams’ previous three movies, died in 2016.

Plans to bring back the cast have been percolating for years, including a 2018 sequel teaming Pine with Kirk’s late father — portrayed in the 2009 film by Chris Hemsworth. The plan ultimately fizzled, reportedly because Paramount couldn’t reach a deal with Pine and Hemsworth. Quentin Tarantino was even circling a project.

Copyright © 2022, ABC Audio. All rights reserved.

Russia-Ukraine live updates: Russia releases video showing more troops leaving Crimea

Russia-Ukraine live updates: Russia releases video showing more troops leaving Crimea
Russia-Ukraine live updates: Russia releases video showing more troops leaving Crimea
filo/Getty Images

(NEW YORK) — The United States continues to warn that Russia could invade Ukraine “any day” amid escalating tensions in the region.

More than 150,000 Russian troops are estimated to be massed near Ukraine’s borders, U.S. President Joe Biden said Tuesday, as U.S. officials have urged all Americans to immediately leave Ukraine.

Biden said Tuesday that the U.S. has “not yet verified” claims by Russian President Vladimir Putin and the Kremlin that Russia was withdrawing some troops from near Ukraine’s borders.

ABC News has learned Putin had told his military forces to be ready to invade by Wednesday, but it remains unclear whether he has made a decision to attack his neighbor. Meanwhile, Ukrainian President Volodymyr Zelenskyy has called for a national day of unity Wednesday.

Russia has denied it plans to invade and has demanded the U.S. and NATO bar Ukraine from joining the military alliance.

Here’s how the news is developing Wednesday. All times Eastern:

Feb 16, 5:36 am
Russia releases video showing more troops leaving Crimea

The Russian military released more videos on Wednesday morning purportedly showing troops pulling back from Moscow-annexed Crimea.

The footage aired on Russian state media, with one video showing a trainload of armour being carried across the Russian-built bridge that connects the Russian-controlled Crimean Peninsula to Russia’s mainland. Another video shows military trucks driving out of Crimea across the bridge, which Russian state media described as support troops leaving “exercises.”

However, officials in the West and regional analysts continue to caution that they have not yet seen significant movements of Russian troops pulling back from near Ukraine’s borders.

Meanwhile, massive military exercises continue in neighboring Belarus and are not due to finish until Sunday. Belarusian Minister of Foreign Affairs Vladimir Makei said Wednesday that “not a single” Russian soldier will remain in the country once those drills end.

Feb 16, 5:05 am
Zelenskyy wishes Ukrainians ‘a happy day of unity’

Ukrainian President Volodymyr Zelenskyy wished citizens “a happy day of unity” on Wednesday.

Zelenskyy had said on Monday evening that instead of Feb. 16 being “the day of the attack,” he would make it “the day of unity” and declared an impromptu national holiday.

ABC News has learned that Russian President Vladimir Putin had told his military forces to be ready to invade Ukraine by Wednesday, but it remains unclear whether he has made a decision to attack the neighboring country.

“We are all united by our wish to live, to live in peace, to live a happy life with our families, parents and children. We have the full right to all of this, because we’re at home here, in Ukraine,” Zelenskyy said in an address on social media Wednesday morning. “Nobody will love our home as much as we do, and nobody can defend our home as we can. I wish you a happy unity day, my blue-yellow ones, a happy day of unity of Ukraine, in the east and west, in the south and north. It works only together, and when it works, we’re strong.”

Copyright © 2022, ABC Audio. All rights reserved.

Scoreboard roundup — 2/15/22

Scoreboard roundup — 2/15/22
Scoreboard roundup — 2/15/22
iStock

(NEW YORK) — Here are the scores from Tuesday’s sports events:

NATIONAL BASKETBALL ASSOCIATION
Atlanta 124, Cleveland 116
Boston 135, Philadelphia 87
Dallas 107, Miami 99
Memphis 121, New Orleans 109
Minnesota 126, Charlotte 120 (OT)
Phoenix 103, LA Clippers 96
Milwaukee 128, Indiana 119

NATIONAL HOCKEY LEAGUE
Buffalo 6, NY Islanders 3
St. Louis 5, Ottawa 2
Tampa Bay 6, New Jersey 3
Pittsburgh 5, Philadelphia 4 (OT)
NY Rangers 2, Boston 1 (SO)
Washington 4, Nashville 1
Calgary 6, Columbus 2
Dallas 4, Colorado 1
Edmonton 5, Los Angeles 2

TOP-25 COLLEGE BASKETBALL
Tennessee 76, Kentucky 63
Villanova 89, Providence 84
Duke 76, Wake Forest 74
Wisconsin 74, Indiana 69
Ohio St. 70, Minnesota 45
Penn St. 62, Michigan St. 58
Texas 80, Oklahoma 78
New Mexico 75, Wyoming 66
Arkansas 76, Missouri 57

Copyright © 2022, ABC Audio. All rights reserved.

Revamp Your Home To Feel Calmer!

Revamp Your Home To Feel Calmer!
Revamp Your Home To Feel Calmer!

Now that we’re home more than ever, we need it to be a place of calm. So here are the things in your home can increase cortisol levels – the stress hormone. This comes from the UCLA Center of Everyday Lives and Families. Rein these in and your life will be a lot calmer:

We’ll start with your kitchen counters. Even if you don’t keep food sitting out – any visual clutter on your counters can raise stress levels. Like having appliances sitting out, mail that needs to be sorted, and cookbooks. And that stress makes us more likely to overeat, and eat unhealthy foods.

Another household stressor is bills and financial papers, like your tax return and receipts. According to the American Psychological Association, 75% of us say finances are a significant source of stress in our lives. So seeing those papers lying around is a constant reminder. That’s why the experts at UCLA say to isolate financial papers in one room of the house.

The experts also say mirrors can be a source of household stress. A report by the Institute of Psychiatry found that looking in a mirror often made people feel stressed about their appearance. So you may want to limit mirrors to the bathroom and a full-length one in the bedroom.

Why Are You More Blue On Monday?

Why Are You More Blue On Monday?
Why Are You More Blue On Monday?

Did you feel more bummed than usual last Monday? This may be the reason: It was “Blue Monday” – and experts say it was the most depressing day of the year. Why?

People are more blue on any Monday.  But if you add in the cold weather, the after-holiday letdown, and credit card bills rolling in then, mix in the disappointment of holiday weight gain, and a lack of exercise – and you’ve got a perfect storm for the blues.

But Blue Monday isn’t the only day of the year that messes with our emotions. Some other bummer days include:

  • Valentine’s Day. Sure, everyone in a relationship is getting roses and chocolates.  But a huge survey found that 70 percent of unattached singles stay home on February 14th and have “psychological stress.”

  • Another hard-to-take day: Tax Day. A Gallup poll of 350,000 people found that “tax day” ranks as one of the most stressful days of the year. In fact, 15 percent of people experience extreme stress on tax day.

  • And winter in general is a depressing time of year for 5 percent of North Americans with seasonal affective disorder – or SAD. It’s a form of depression typically felt from December through March. It’s thought to be caused by decreased exposure to sunlight during the winter months – which explains why it’s 10 times more common in Alaska than in Florida.