Who could Elon Musk choose as the next Twitter CEO?

Who could Elon Musk choose as the next Twitter CEO?
Who could Elon Musk choose as the next Twitter CEO?
David Paul Morris/Bloomberg via Getty Images

(NEW YORK) — Elon Musk earlier this month pledged to step down as the head of Twitter as soon as he finds someone “foolish enough to take the job.”

Musk’s tentative resignation followed a Twitter poll posted by the billionaire entrepreneur in which 57.5% of respondents called on Musk to stop leading the company. Musk said he will retain control over the software and server departments, important teams that will grant him significant control over how the social media platform operates.

It remains possible that Musk may reverse his decision to step down, since he has changed his mind about previous policy decisions at Twitter, such as a proposed content moderation council, which he ultimately abandoned.

He hasn’t shared further details on the search for a successor or the traits he’s looking for in one, but that ambiguity hasn’t stopped some candidates from putting their names forward, including rapper Snoop Dogg and YouTube personality Mr. Beast.

Still, a set of viable candidates will likely emerge in the coming weeks or months.

The position brings formidable challenges. ​​Musk, who admitted he overpaid for the platform at the purchasing price of $44 billion, said last month that the company was losing $4 million a day.

Since Musk retains a major public profile and ultimate authority as owner, the incoming CEO will need to implement Musk’s vision and cede the spotlight, Peter Harms, a professor of management at the University of Alabama who has studied corporate leadership, told ABC News.

“It’s not going to be your typical CEO,” Harms said.

Twitter did not immediately respond to a request for comment.

Here’s a list of who could be the next CEO of Twitter:

People close to Elon Musk

The next CEO of Twitter is perhaps most likely to come from a group of people close to Musk, whether inside or outside the company.

Jason Calacanis, a friend and public supporter of Musk, carries years of experience in tech and media. A former general manager at Netscape, Calacanis now works as an angel investor with stakes in Robinhood and Uber, among other startup successes.

Another friend of Musk’s, David Sacks, is co-founder and partner at a venture capital firm called Craft, which boasts investments in Lyft, Palantir, Slack and Twitter.

Earlier this month, Calacanis tweeted a poll asking users whether he, Sacks, or a partnership of the two should run Twitter after Musk. The response that garnered the most support was “Other,” which drew 39% of the vote.

A couple of other individuals in Musk’s orbit have drawn attention since his resignation announcement: Sriram Krishnan, a former Twitter employee brought back by Musk in October to help make improvements; and Steve Davis, the CEO of another Musk venture called The Boring Company, who reportedly slept at Twitter headquarters with his wife and newborn to help out with the acquisition, business publication The Information reported.

John Legere

Amid the flurry of half-joking celebrity requests asking to lead Twitter, an experienced candidate volunteered himself for the position: John Legere, former CEO of telecom company T-Mobile.

Legere, who led T-Mobile from 2012 to 2020, drew plaudits for rescuing T-Mobile from difficult times and making it the third-largest mobile carrier in the U.S.

In a Twitter post addressed to Musk, in November, Legere said, “You can stop managing daily business, and ‘content moderation’ and then support product/technology, let someone else ‘run’ @Twitter.”

“I’m expensive but so is what you paid for Twitter,” he added.

Jeffrey Sonnenfeld, a professor of management at Yale University who convenes gatherings of top CEOs, told ABC News that Legere’s skills match the job, since he knows how to resurrect a well-established company.

Legere “could parachute in tomorrow and make it a lot better,” Sonnenfeld said. “This is a turnaround, a recovery, not an entrepreneurial start up.”

For his part, Musk appeared to rebuke Legere’s candidacy. In response to Legere’s post suggesting he lead the company, Musk simply tweeted, “no.” However, Musk has reversed his position on major decisions before, including the acquisition of Twitter.

Jack Dorsey

Another potential candidate to run Twitter is former CEO Jack Dorsey, a friend of Musk’s who departed the company and returned to lead it on a previous occasion.

Dorsey, who helped found the social media company, posted the platform’s first tweet in 2006 and was named CEO a year later. However, his tenure only lasted until 2008. Years later, however, as user growth plateaued and employee morale flagged, Dorsey came back to lead the company from 2015 to 2021.

Currently, Dorsey runs Block, a fintech company formerly called Square, which he co-founded more than a decade ago.

The return of a former Twitter CEO, like Dorsey, may be unlikely, since Musk has reversed some of the company’s previous policies and sharply criticized others. The company’s decision to ban former President Donald Trump after the Jan. 6 attack, one of the most high-profile choices made under Dorsey, was undone by Musk last month.

Further, Musk has granted journalists access to internal company documents for a series of stories called the “Twitter Files,” in which they allege bias and censorship previously undertaken by the platform.

Meanwhile, Dorsey said in May that he does not want the role of CEO. When a user predicted that Musk would ultimately appoint Dorsey as CEO, Dorsey replied, “Nah I’ll never be CEO again.”

Sheryl Sandberg

Few potential candidates boast the qualifications of Sheryl Sandberg, who stepped down as chief operating officer at Facebook-parent Meta in September.

Facing a pause in advertising from major brands, Sandberg could restore the platform’s credibility on Madison Avenue and ensure that the company optimizes revenue through other means.

Sandberg, who joined Meta in 2008, led a dramatic increase in Facebook’s revenue by revamping its advertising business, turning the operation into an industry powerhouse that helped small and large businesses target users through data collected by the platform. Before that, she served as vice president of global online sales and operations at Google.

She worked closely with Meta Founder and CEO Mark Zuckerberg for nearly 15 years, navigating a relationship with a higher-ranking, tech-focused executive that bears resemblance to the possible dynamic between an incoming Twitter CEO and Musk.

But the sources of potential tension between Musk and Sandberg are manifold. Sandberg holds a significant public profile of her own, built in part on Lean In, a 2013 book that encouraged women to be assertive in the workplace. A powerful CEO, as Sandberg would likely be, could face disputes with Musk over the direction of the company.

Musk and Sandberg could also clash over their political views, especially as content moderation remains a polarizing issue. Sandberg was a major donor to Democratic nominee Hillary Clinton’s 2016 presidential campaign. By contrast, Musk last month encouraged Americans to vote for Republicans ahead of the midterm elections.

Copyright © 2022, ABC Audio. All rights reserved.

Lawsuit alleges Apple Watch’s blood oxygen sensor ‘racially biased’; accuracy problems reported industry-wide

Lawsuit alleges Apple Watch’s blood oxygen sensor ‘racially biased’; accuracy problems reported industry-wide
Lawsuit alleges Apple Watch’s blood oxygen sensor ‘racially biased’; accuracy problems reported industry-wide
hocus-focus/Getty Images

(NEW YORK) — Apple is facing a proposed class action lawsuit alleging the Apple Watch’s blood oxygen sensor is racially biased against people with dark skin tones.

Experts say accuracy problems have been reported for these devices industry-wide. It’s not clear if Apple’s products are any better or worse than others.

The product’s feature, the Blood Oxygen app, allows users to measure their blood oxygen level directly from their wrist, according to Apple’s website.

The lawsuit claims plaintiff Alex Morales was aware of this feature when he purchased an Apple Watch between 2020 and 2021, assuming it would work “without regard to skin tone.”

Morales alleges Apple did not disclose any potential “biases and defects” on the product’s label, despite a large body of research indicating similar pulse oximetry devices — usually placed on a fingertip — were “significantly less accurate in measuring blood oxygen levels based on skin color,” the lawsuit states.

“The ‘real world significance’ of this bias lay unaddressed until the middle of the coronavirus pandemic, which converged with a greater awareness of structural racism which exists in many aspects of society,” according to the lawsuit, which was filed on Dec. 24.

Pulse oximetry devices were widely used during the COVID-19 pandemic to monitor patients’ conditions, which would help determine whether they received certain medicines, oxygen therapies and hospital beds when all were in limited supply.

The devices work by shining a light into a person’s finger or wrist and sensing how much is absorbed by their red blood cells, ABC News medical contributor Dr. Darien Sutton said.

“How much light is absorbed tells you how much oxygen you have because red blood cells carry oxygen,” he said. “The problem is that darker skin also absorbs light, so it can give you a falsely elevated reading.”

While it has been known for decades that the technology tends to overestimate oxygen levels for darker-skinned patients, recent medical studies highlighted the negative impact on such patients. For example, Hispanic and Black patients with the coronavirus were less likely to be recognized as eligible for treatment, according to a study published in May.

Researchers say reliance on the technology and the potentially flawed readings it yielded may have contributed to greater deaths among Black and other dark-skinned patients during the pandemic.

In light of these studies, the Food and Drug Administration recently launched a review of pulse oximeter technology to improve its efficacy and accuracy for all skin pigmentations.

It is unclear if Apple’s technology carries the same problem. An October study found the commercial smartwatch’s blood oxygen sensor is on par with “medical grade” devices, though there was no mention of including people of color in the study.

Apple did not immediately respond to ABC News’ request for comment. The company released its own observational study in June, which found that blood oxygen level readings were not meaningfully different between white Apple Watch wearers and nonwhite users.

The company’s website also states that measurements taken with the Blood Oxygen app are “not intended for medical use and are only designed for general fitness and wellness purposes.” Pulse oximeters used in hospitals must meet a higher standard of testing and accuracy, Sutton said.

Doctors stress that anyone who is struggling to breathe should seek emergency care, and at-home devices are prone to false readings due to human error, and a range of other issues.

While the website makes no mention of a user’s natural skin color interfering with the device, it does include a disclaimer that “permanent or temporary changes to your skin, such as some tattoos, can also impact performance” of the Blood Oxygen app. In 2015, several Apple Watch users said their black wrist tattoos interfered with the device’s heart rate sensor.

Morales filed the lawsuit on behalf of all New Yorkers who purchased an Apple Watch during the statutes of limitations. He also sued on behalf of residents in Alaska, Arkansas, Idaho, Iowa, Mississippi, North Carolina, North Dakota, Utah and Wyoming under those states’ consumer fraud laws.

The lawsuit also accuses Apple of breaches of express warranty, fraud and unjust enrichment, claiming violations of New York General Business Law and State Consumer Fraud Acts.

Morales’ attorney Spencer Sheehan told ABC News that as scientists work to improve pulse oximeter technology, Apple has an obligation to be transparent with consumers about its devices’ possible flaws.

“It’s not comfortable to recognize and to acknowledge that this technology has an inherent bias,” Sheehan said. “But I think that we have to do that in order to chart a better path forward, to have a technology that does a better job in terms of the information it provides without accounting for a person’s skin tone.”

Copyright © 2022, ABC Audio. All rights reserved.

How to get refunds for canceled flights

How to get refunds for canceled flights
How to get refunds for canceled flights
E4C/Getty Images

(NEW YORK) — A massive storm has triggered widespread flight cancellations, most notably at Southwest Airlines, which has canceled more than 15,000 flights since last week, stranding droves of customers during peak holiday travel season.

The problems continued for passengers on Thursday, when Southwest canceled about 2,300 flights or 58% of its flights scheduled for that day, according to flight tracking site FlightAware. But the company said in a statement that it plans to return to “normal operations with minimal disruptions” on Friday.

After a flight cancellation, airlines are typically willing to rebook passengers on the next available flight. Since flights are scarce and some airlines are overwhelmed, customers may prefer a refund.

Any potential refund depends on a passenger’s communication with the airline, Clint Henderson, a managing editor for news at The Points Guy, told ABC News.

“Be your own best advocate,” he said. “You really have to appeal to the airline directly – there’s no third party that takes care of it for you.”

Here’s how to get a refund if your flight has been canceled:

Seek a cash refund for the ticket

If an airline cancels a flight and a customer decides that he or she does not want to rebook an alternative one, the customer is entitled to a full refund by law, according to the Department of Transportation. That requirement applies no matter the reason for the flight cancellation, the agency said.

In such a circumstance, the customer can demand reimbursement directly from the airline, Henderson said.

“A lot of times airlines will try to give you a voucher but you’re entitled to cash back,” he said.

Pursue a refund for food, lodging and other expenses

In light of the holiday disruption that has stranded many customers, Southwest Airlines has vowed to “honor reasonable requests for reimbursement for meals, hotel, and alternate transportation,” the company said.

The offer to refund non-flight expenses only stands for customers who suffered a cancellation or “significant delay” between Dec. 24 and Jan. 2, Southwest Airlines said.

It remains unclear exactly what costs Southwest Airlines will cover. Before affected customers take on sizable costs, they should note that “there’s a lot of wiggle room in the word ‘reasonable,'” Henderson said.

Ultimately, Southwest Airlines will refund customers for food, travel and lodging fees, even if they exceed typical rates, Henderson predicted, since the company will want to restore its reputation and respond to criticism from elected officials.

“I do think they’ll make good even if you’re spending $1,000 on a last-minute flight or renting a car for $300 a day or airport hotel prices jumped dramatically and you spend $500 a night for a hotel,” he said.

Send receipts to the airline as soon as possible

Southwest Airlines has posted a web page where customers can submit receipts for expenses that resulted from travel disruptions over the holidays.

The company has warned, however, that reimbursements may take an extended period of time due to the severity of the current problems.

“As our focus remains on stabilizing and restarting our operation, of which we’re seeing very positive signs, our teams will then take on the task of processing the requests. It will take some time given the scale,” Southwest Airlines told ABC News.

In turn, customers can expedite the process as much as possible by submitting receipts to the company soon after the relevant purchases.

Henderson said he did not know how long reimbursements would take but said customers should not expect them anytime soon.

“Usually this kind of thing takes weeks and weeks, if not months,” he said. “I don’t think there will be a speedy timeline.”

Copyright © 2022, ABC Audio. All rights reserved.

The Year in Music 2022: Morgan Wallen bounces back big in 2022

The Year in Music 2022: Morgan Wallen bounces back big in 2022
The Year in Music 2022: Morgan Wallen bounces back big in 2022

2021 was a year filled with controversy for Morgan Wallen, after he was caught on video in February of that year using a racial slur, but the East Tennessee native bounced back in a big way in 2022. 

Morgan took home the ACM Album of the Year trophy for his double set, Dangerous, and also picked up two CMA noms, including one for the prestigious Entertainer of the Year title. The Academy of Country Music also gave Wallen its Milestone Award in recognition of his impact on the genre, including the album’s 63-week stay at the top of the country albums chart.

Dangerous also broke the Billboard record for the most time a singular artist spent in the Billboard 200 all-genre album chart, with 86 non-consecutive weeks. Additionally, Wallen became the first artist to simultaneously hold the top three spots on Billboard‘s streaming, airplay and sales-based Hot Country Songs chart.

In 2023, Morgan heads out on his One Night at a Time World Tour, which includes 26 stadium shows, as well as stops in Australia, New Zealand, and Canada.

Copyright © 2022, ABC Audio. All rights reserved.

Ryan Seacrest: ‘New Year’s Rockin’ Eve’ brings you “what was fun this year” in music, songs “everybody can sing along to”

Ryan Seacrest: ‘New Year’s Rockin’ Eve’ brings you “what was fun this year” in music, songs “everybody can sing along to”
Ryan Seacrest: ‘New Year’s Rockin’ Eve’ brings you “what was fun this year” in music, songs “everybody can sing along to”
ABC

Saturday at 8 p.m. ET on ABC’s Dick Clark’s New Year’s Rockin’ Eve with Ryan Seacrest, Ryan and co-host Liza Koshy will be counting down to 2023 in New York City’s Times Square. They’ll be joined by two hot artists of today, as well as two iconic groups who’ll bring the ’80s and ’90s nostalgia.

“We have Duran Duran just before midnight, doing a huge medley of their biggest hits,” Ryan tells ABC Audio. “J-Hope [from BTS] is going to be here. Jax is performing — I met Jax on American Idol years ago. We also have New Edition coming on stage — all the guys from New Edition … then, of course, Dove Cameron, Wiz Khalifa and a list of others out [on the] West [Coast].”

Ryan, who’ll host season 21 of American Idol starting February 19, is particularly happy about season 14’s Jax breaking through with “Victoria’s Secret” this year.

“I’m loving the fact that it’s full circle that she’s on the show,” he notes.

The LA Party segment of the show also includes Nicky Youre and Armani White, while the Disneyland segment features Ciara, Fitz & The Tantrums, Halle Bailey, Shaggy and Lauren Spencer-Smith. Plus, Billy Porter will sing from New Orleans, and Farruko will perform from Puerto Rico.

With such a diverse lineup, you may wonder who chooses the Rockin’ Eve performers each year. Does Ryan get a say in who he’ll be sharing the stage with?

“It’s a consensus,” he explains. “We have a booking department that works very hard … but sure, we talk about who we think would fit, certainly, those live spots in Times Square — and also represent what was fun this year and also what’s fun to celebrate from years ago, like Duran Duran, and those songs everybody can sing along to.” 

Copyright © 2022, ABC Audio. All rights reserved.

The Year in Music 2022: Sudden losses rock the hip-hop world

The Year in Music 2022: Sudden losses rock the hip-hop world
The Year in Music 2022: Sudden losses rock the hip-hop world

The hip-hop world suffered some devastating losses in 2022, the most high profile of which was the death of Migos rapper Takeoff.

Takeoff, born Kirshnik Khari Ball, was fatally shot at 810 Billiards & Bowling in Houston on November 1. He was 28. 

Fans and fellow artists, including his bandmates Quavo and Offset, and Offset’s wife, Cardi B, were left reeling from the loss and paid tribute to him on social media. Thousands gathered at the State Farm Arena in Atlanta, Georgia, to pay their respects at a public memorial on November 11.

In December, a suspect was arrested and charged with his murder.

Here are some of the other artists we mourned this year:

Coolio –  The Grammy-winning rapper, record producer and actor best known for his 1995 hit “Gangsta’s Paradise” died September 28 at the age of 59. A cause of death for the artist, born Artis Leon Ivey Jr., has not yet been revealed.

PnB Rock – The up-and-coming rapper, born Rakim Hasheem Allen, was fatally shot on September 12 during a robbery at Roscoe’s Chicken & Waffles in South Los Angeles. He was 30 years old.

B. Smyth – The R&B singer died November 17 of “respiratory failure after a long battle with pulmonary fibrosis,” according to his brother. Born Brandon Smith, he was known for his 2014 song “Twerkaholic” and his 2012 collab with 2 Chainz, “Leggo.”

JayDaYoungan – The Louisiana rapper, born Javorius Scott, was shot and killed in July in his hometown of Bogalusa, police confirmed in a Facebook post. He was 24.

Trouble – The Atlanta rapper was shot and killed in a domestic situation in June. The artist, born Mariel Semonte Orr, was 34.

Jesse Powell – The R&B singer and Grammy nominee passed away peacefully at his Los Angeles home in September. He was 51. His cause of death was not revealed.

DJ Kay Slay – The legendary New York DJ, born Keith Grayson, died in April after a monthslong battle with COVID-19. He was 55.

Copyright © 2022, ABC Audio. All rights reserved.

The Year in Music 2022: Adele craps out in Las Vegas, then hits the jackpot

The Year in Music 2022: Adele craps out in Las Vegas, then hits the jackpot
The Year in Music 2022: Adele craps out in Las Vegas, then hits the jackpot
Raven B. Varona

Since she became a global superstar, Adele has rarely put a foot wrong. But in 2022 she experienced backlash after abruptly canceling her Las Vegas residency — something she called “the worst moment in my career, by far.”

–The saga started in November 2021 when, shortly after telling Rolling Stone that she wasn’t going to do a Las Vegas residency because there were no venues available for her, Adele announced Weekends with Adele.  The production was planned to run on weekends from January through April 2022 at the Colosseum at Caesars Palace.

–Prices soared for the shows, Adele’s first in the U.S. since 2016, with at least one last-minute website offering seats for as much as $49,000 each for the opening night.

–But it all came crashing down on Thursday, January 20 — one day before the residency was to launch. In an emotional video message that day, Adele called the whole thing off, telling fans, “I’m so sorry, but my show ain’t ready.” She blamed COVID and delivery delays, adding, “I’m so upset and I’m really embarrassed and I’m so sorry to everyone that traveled in.”

–Fans who’d spent thousands on hotel and airfare to fly in for the opening weekend were furious and also frustrated Adele offered no further explanation. Rumors swirled as to the “real” reason the show was called off; there was speculation that she’d have to switch venues if she ever did make it to Vegas.

–In February, Adele appeared on The Graham Norton Show and insisted that the residency was “absolutely 100 percent happening this year.”

–In early July, Adele told BBC 4’s Desert Island Discs that she was “a shell of a person for a few months” after canceling the show, adding, “I definitely felt everyone’s disappointment … it was brutal.” She also explained her lack of communication by saying, “I’m not gonna update you if I ain’t got nothing to update you with, because that just leads to more disappointment.”

–Finally, in late July, the word came: Weekends with Adele had been rescheduled for November 18, 2022, through March 25, 2023, and eight new shows had been added. In August, she told ELLE magazine that canceling the residency was “the worst moment in my career, by far,” but insisted she had to because the show had “no soul in it” and “lacked intimacy.”

–But all’s well that ends well: When it finally premiered, the show, which features her performing with a string section amid video panels, a rain curtain, fire and clouds of confetti, got rave reviews.

Adele has since added two New Year’s Eve weekend shows to the run, and she told an audience in December that, rather than returning to arenas or stadiums, she might simply continue doing intimate shows like Weekends with Adele “for the rest of my life.”

Copyright © 2022, ABC Audio. All rights reserved.

The Year in Rock 2022: The world keeps “Beggin'” for more Måneskin

The Year in Rock 2022: The world keeps “Beggin'” for more Måneskin
The Year in Rock 2022: The world keeps “Beggin'” for more Måneskin

Following their breakout in 2021, Måneskin‘s meteoric rise didn’t slow down in 2022.

The Italian rockers first popped on the world’s radar when they won last year’s Eurovision Song Contest. They soon made a name for themselves stateside with their viral cover of The Four Seasons‘ “Beggin'” and the single “I Wanna Be Your Slave.”

Picking up where they left off, Måneskin kicked off 2022 with their debut performance on Saturday Night Live, which would foreshadow a year of firsts for the band, including playing big festivals like Coachella and Lollapalooza for the first time. In the fall, they launched their first North American headlining tour, much of which was sold out.

In between all their time on the road, Måneskin continued to release new music with the singles “Supermodel” and “The Loneliest,” as well as a cover of “If I Can Dream” for the Elvis biopic. “Supermodel” would hit #1 on Billboard‘s Alternative Airplay chart.

Måneskin also picked up a number of award nominations throughout the year, winning an MTV Video Music Award and an American Music Award. They performed on the VMAs, as well, though their performance was largely censored during the TV broadcast due to wardrobe issues.

The Måneskin train doesn’t appear to be losing any steam as we head into 2023. The group’s new album, Rush!, is set to drop January 20, and they’re nominated for Best New Artist at the 2023 Grammys, taking place February 5.

Copyright © 2022, ABC Audio. All rights reserved.

The Year in Rock 2022: New tour, new album, ticket controversy and more for Bruce Springsteen

The Year in Rock 2022: New tour, new album, ticket controversy and more for Bruce Springsteen
The Year in Rock 2022: New tour, new album, ticket controversy and more for Bruce Springsteen
Danny Clinch

It was quite a year for Bruce Springsteen fans, who saw The Boss announce a new tour, but then anger them with ticket prices. He also released a new album, made several surprise concert appearances and more.

Here are some of the Bruce Springsteen happenings in 2022:

–Bruce and the E Street Band announced that their first tour in six years would hit Europe and the U.S., first revealing European dates that kick off in April in Barcelona.

–During Coldplay’s Music of the Spheres tour stop at MetLife Stadium in New Jersey, Bruce hopped onstage to join them for performances of his “Working on a Dream” and “Dancing in the Dark.”

–Also at MetLife Stadium, Bruce helped Paul McCartney wrap up his Got Back Tour in the U.S., joining Sir Paul to perform his “Glory Days” and the early Beatles track “I Wanna Be Your Man.”

–Less than two weeks later, Bruce showed up for McCartney once again, joining him for his historic headlining set at the Glastonbury Music Festival in England. The pair played the same two songs they performed in Jersey.

–Bruce and the E Street Band finally announced North American dates for their 2023 tour, which will kick off February 1 in Tampa, Florida. While fans were excited, that changed when tickets actually went on sale. Many were unable to get them, and those who got through to Ticketmaster found ticket prices as high as $5,000 thanks to the site’s dynamic pricing, which raises prices based on demand.

–Bruce responded to the backlash later in the year, telling Rolling Stone that while in the past he has always priced his tickets “under market value,” this time, at 73, he told his team, “I want to do what everybody else is doing, my peers.” He did insist most of his tickets were “affordable.” He also noted that artists “have to own the decisions you made,” adding, “I think if folks come to the show, they’re going to have a good time.”

–Bruce and wife Patti Scialfa became grandparents for their first time when their youngest son, Sam, welcomed daughter Lily Harper Springsteen.

–The Boss turned up at Bleachers’ Radio City Music Hall show in New York, joining Jack Antonoff to perform their collaborative tune “Chinatown.”

–September 30 marked the 40th anniversary of Bruce’s acclaimed solo album “Nebraska.”

–Bruce made a surprise appearance at The Killers’ show at Madison Square Garden, where he joined Brandon Flowers to perform his “Badlands” and “Born to Run,” as well as The Killers’ “Mr. Brightside” and “A Dustland Fairytale.”

–He made his annual appearance at the Stand Up For Heroes benefit in New York, where he played a four-song set and told his traditional dirty jokes.

–Bruce dropped the new album Only The Strong Survive, made up of covers of classic soul songs like “Don’t Play That Song” and “Night Shift.” The album debuted at eight on the Billboard 200 album chart, his 22nd top 10 record, landing him at eight for the most top 10 albums and at six for the most among solo artists.

–During a week of appearances on The Tonight Show with Jimmy Fallon, Bruce confirmed that the often-debated line in “Thunder Road” is “Mary’s dress sways,” although he read what was written on the Born to Run jacket. Despite saying he was “insane about every little detail” about the album, it does, in fact, read “Mary’s dress waves.” Bruce insisted “this is wrong.”

Copyright © 2022, ABC Audio. All rights reserved.

House investigation finds FDA, drug firm Biogen ignored internal concerns for Alzheimer’s drug

House investigation finds FDA, drug firm Biogen ignored internal concerns for Alzheimer’s drug
House investigation finds FDA, drug firm Biogen ignored internal concerns for Alzheimer’s drug
Sarah Silbiger/Getty Images, FILE

(WASHINGTON) — A congressional investigation into the Food and Drug Administration’s review process for an Alzheimer’s treatment found that the agency “deviated” from its standard procedures to approve the Aduhelm drug with inconsistent data.

Aduhelm is notable for being the first drug in recent years approved to treat the underlying cause of Alzheimer’s, a disease with no known cure that is characterized by progressive dementia that affects more than six million Americans, according to the Alzheimer’s Association.

The joint 18-month investigation between the House’s Oversight and Reform Committee and Energy and Commerce Committee, released on Thursday, criticizes the FDA for “atypical collaboration and interactions” with Biogen, the drug’s manufacturer.

In statements, Biogen and the FDA both said their interactions prior to Aduhelm’s green light were appropriate in the context of the approval process.

“One of my top priorities as Chair of the Committee on Oversight and Reform is ensuring that the American people have access to effective and affordable medications,” Rep. Carolyn Maloney, D-N.Y., chairwoman of the House Oversight and Reform Committee, said in a statement.

The FDA “remains committed to the integrity of our drug approval process, which includes ensuring that safe and effective new treatment options are available to the millions of people with Alzheimer’s disease living in the U.S.,” the agency said in a statement to ABC News.

“The FDA’s decision to approve Aduhelm was based on our scientific evaluation of the data contained in the application, which is described in the approval materials. … That said, the agency has already started implementing changes consistent with the Committee’s recommendations,” the statement said, in part.

The report also blasts Biogen for “an unjustifiably high price for Aduhelm” that it says was meant “to make history.” One year of the Aduhelm treatment originally cost $56,000 for a person of average weight, the report says.

“Biogen stands by the integrity of the actions we have taken,” the company said in a statement to ABC News. “As stated in the congressional report, an FDA review concluded that, ‘There is no evidence that these interactions with the sponsor in advance of filing were anything but appropriate in this situation.'”

“Alzheimer’s is a highly complex disease and we have learned from the development and launch of Aduhelm. That process is continuing to inform our work as Biogen introduces new innovative treatments to the market,” the statement read, in part.

Aduhelm was considered for FDA approval under the agency’s traditional pathway before the agency switched to consider the drug under its Accelerated Approval Program, according to the report.

The change in course — which the congressional investigation says occurred “abruptly” — came after the FDA internally found Aduhelm lacked “demonstrated clinical benefit necessary for traditional approval,” House investigators found.

Under the accelerated program, the FDA can approve some drugs that meet both “an unmet medical need” and “treat serious conditions,” according to the agency’s website. Aduhelm is not the only drug to be approved under this pathway, which the FDA carved out specifically to give more options to patients with diseases for which virtually no treatments exist. Accelerated approval is typically contingent upon the pharmaceutical company completing larger, longer-term studies.

During the monthslong approval process, the FDA and Biogen collaborated closely. FDA and Biogen officials met, spoke or otherwise had substantial email exchanges at least 115 times, according to the congressional investigation.

Although it is typical for drug companies to work closely with the FDA during the approval process, such collaboration between Biogen and its federal regulators “exceeded the norm in some respects,” according to the FDA’s own internal review, the report says.

The cooperation came after an independent review of Aduhelm’s effects on people with Alzheimer’s cast doubt on its ability “to effectively slow cognitive and functional impairment” in patients.

And when the FDA initially approved the drug for all Alzheimer’s patients, the congressional investigation found that the move concerned some Biogen advisers who were wary of such broad approval. The advisers did not communicate such reservations to regulators, the report says.

The FDA later walked back its broad approval of the drug, eventually recommending the drug’s use in only a narrower subset of patients with early-stage disease, which more closely mirrored the group included in Aduhelm’s clinical trials.

Following the FDA’s accelerated approval of Aduhelm, the Centers for Medicare & Medicaid Services established that Medicare would only pay for the drug under limited circumstances in which patients are part of approved studies.

That move severely limits the availability and practical implications of Aduhelm, essentially making it available only to people who can pay out of pocket for treatment.

And as part of the stipulations associated with accelerated approval, Biogen has more than six years to complete the final trial, per the report. Aduhelm remains available in the meantime.

Thursday’s report comes as the FDA evaluates two additional Alzheimer’s-related drugs, with a green light from the agency possible in the coming months. Biogen helped develop one of those drugs.

“FDA must take swift action to ensure that its processes for reviewing future Alzheimer’s disease treatments do not lead to the same doubts about the integrity of FDA’s review,” the congressional report says.

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