Weight loss drugs like Ozempic may help reduce overdose risks: Study

Weight loss drugs like Ozempic may help reduce overdose risks: Study
Weight loss drugs like Ozempic may help reduce overdose risks: Study
Iuliia Burmistrova/Getty

(NEW YORK) — A new study suggests that GLP-1 agonist medications like Ozempic, which are used for diabetes management and weight loss, may help reduce the risk of overdose and alcohol intoxication in people with substance use disorders.

“It helps to underline another significant benefit of this class of medication,” Dr. Angela Fitch, the co-founder, and chief medical officer of knownwell, a company that provides weight-inclusive health care, told ABC News.

The large study, published in the journal, Addiction, analyzed the health records of 1.3 million people from 136 U.S. hospitals for nearly nine years. That included the records of 500,000 people with opioid use and more than 800,000 with alcohol use disorder.

Those who took Ozempic or a similar drug had a 40% lower chance of overdosing on opioids and a 50% lower chance of getting drunk compared to those who didn’t take the medication, the study found.

“The existing medications for treating substance use disorder are underutilized and stigmatized,” said Fares Qeadan, associate professor of biostatistics at Loyola University in Chicago. “These medications intended for diabetes and weight loss can help addiction without the associated stigma, which will be a new window for how to deal with addiction.”

The protective effects were consistent and even applied to people with Type 2 diabetes, obesity, or both conditions.

Fitch expressed optimism about the study’s results.

“As clinicians, recognizing that people can get double benefits from something is always helpful and as more obesity medications enter the market, this can help personalize treatments,” she said.

GLP-1 drugs, such as Ozempic and the combination drug tirzepatide also included in the study, mimic a natural hormone known as glucagon-like peptide-1 to help regulate blood sugar and insulin levels. For managing obesity and diabetes, these medications work by slowing digestion, reducing appetite, and enhancing insulin release in response to meals.

Scientists don’t fully understand how these drugs work yet. Some studies indicate that they activate specific “reward” receptors in the brain that make high-calorie foods less gratifying, so users eat less.

This could also be the reason these drugs may reduce cravings for alcohol and opioids. For example, a previous study found that adding the GLP-1, exenatide, was effective at helping some people with obesity and alcohol use disorder drink less.

The Addiction study does not prove that GLP-1 medications directly lower the risks of opioid overdose and alcohol intoxication, only that people taking them seemed to be helped. And it only included hospitalizations so it’s not clear if they will work as well in less serious cases.

Prescribing the drugs to treat substance use, at least for now, isn’t possible because they aren’t approved by the U.S. Food and Drug Administration for that purpose, Fitch pointed out.

“One of the challenges that we have as clinicians is we know that some of these benefits help patients. And not being able to get them access is very challenging,” she said.

People with substance use disorder keep using drugs or alcohol even though it causes problems in their life. According to the CDC, there are 178,000 annual deaths linked to excessive drinking. Over 75% of drug overdose deaths in 2022 involved opioids.

If you or someone you know is living with substance use disorder, free, confidential help is available 24 hours a day, seven days a week, by calling or texting the national lifeline at 988.

Dr. Faizah Shareef is an Internal Medicine Resident Physician and a member of the ABC News Medical Unit.

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Florida man arrested for threatening utility workers restoring power after Hurricane Milton

Florida man arrested for threatening utility workers restoring power after Hurricane Milton
Florida man arrested for threatening utility workers restoring power after Hurricane Milton
Robert Brook/Getty Images

(NEW YORK) — A man was arrested Wednesday for threatening utility workers who were restoring power in Hillsborough County, Florida, following mass outages caused by Hurricane Milton, according to officials.

Crews were working on a road repair when the man allegedly verbally threatened them and drove his vehicle toward them in an intimidating manner.

The Hillsborough County Sheriff’s Office has identified the suspect as 57-year-old Kenneth Ray Velasco.

When the incident occurred, a power line crew was working on a road that was closed for repairs, creating a traffic delay. The man was in his vehicle and grew impatient.

He backed into a utility pole and fence, causing an estimated $1,000 in damage, according to official reports, and then attempted to flee the scene.

When the linemen tried to prevent him from leaving, he drove toward them in a deliberate manner that caused them to jump out of the way and also threatened to shoot them, officials said.

“Linemen have been working tirelessly to restore power after the storm,” said Sheriff Chad Chronister. “For this person to threaten their lives and deliberately endanger them, all because of a traffic delay, shows a disturbing lack of regard for the safety of others and the critical work being done.”

Velasco was pulled over in a traffic stop and charged with aggravated assault and felony criminal mischief for vandalism of property, according to the sheriff’s office.

He was arrested without incident, officials said.

“We’re grateful no one was seriously hurt, and this suspect will face the full extent of the law for his egregious crimes,” the sheriff said.

As of Wednesday evening, nearly 20,000 residents of Hillsborough County are without power.

The investigation into the incident is ongoing.

ABC News’ Victoria Arancio contributed to this report.

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US military strikes Houthi targets in Yemen

US military strikes Houthi targets in Yemen
US military strikes Houthi targets in Yemen
KeithBinns/Getty Images

(WASHINGTON) — The U.S. military has struck Houthi weapons storage facilities within Houthi-controlled areas of Yemen, U.S. officials told ABC News.

“U.S. Central Command forces conducted multiple airstrikes on numerous Iran-backed Houthi weapons storage facilities within Houthi-controlled areas of Yemen,” a U.S. defense official said.

The defense official said the weapons were used to “target military and civilian vessels navigating international waters throughout the Red Sea and Gulf of Aden.”

Defense Secretary Lloyd Austin confirmed that B-2 strategic stealth bombers were used in the strikes against “five hardened underground weapons storage locations in Houthi-controlled areas of Yemen.”

His statement also hinted that using such significant aircraft for the job was meant to send a signal to other bad actors in the region.

“The employment of U.S. Air Force B-2 Spirit long-range stealth bombers demonstrate U.S. global strike capabilities to take action against these targets when necessary, anytime, anywhere,” it said.

Austin’s statement also boasted of the military’s “ability to target facilities that our adversaries seek to keep out of reach, no matter how deeply buried underground, hardened, or fortified.”

U.S. Central Command said in a statement: “These actions were taken to degrade the Houthi’s capability to continue their reckless and unlawful attacks on international commercial shipping.”

Early assessments indicate no civilian casualties, according to CENTCOM.

This is a developing story. Please check back for updates.

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Fate of 2 Navy airmen remains a mystery after jet crashes near Washington’s Mount Rainier: Officials

Fate of 2 Navy airmen remains a mystery after jet crashes near Washington’s Mount Rainier: Officials
Fate of 2 Navy airmen remains a mystery after jet crashes near Washington’s Mount Rainier: Officials
EA 18-G Growler Navy Jet Fighter. Via Education Images/Universal Images Group via Getty Images

(WASHINGTON) — The fate of two U.S. Navy pilots remained a mystery Wednesday, a day after their fighter jet crashed during a routine training flight and search-and-rescue crews reported finding no sign of them in the rugged landscape of northeast Washington.

Wreckage of the EA-18G Growler jet was located Wednesday afternoon but the search continues for the two-person crew, military officials said in an update on Wednesday. The crash site is a mountainside east of Mount Rainier, officials said.

“Responders are facing mountainous terrain, cloudy weather, and low visibility as the search is ongoing,” Navy officials said in an earlier statement Wednesday afternoon.

The jet, from Electronic Attack Squadron 130, crashed at about 3:23 p.m. on Tuesday about 30 miles west of Yakima on the eastern side of Mount Rainier, according to the Navy.

The jet crashed after launching a training flight from Naval Air Station Whidbey Island, officials said.

An MH-60S helicopter crew was immediately launched to search for the missing airmen and wreckage, officials said. Additional rescue units from the U.S. Navy Fleet Reconnaissance Squadron One, Patrol Squadron, Naval Air Station Whidbey Island Search and Rescue and the U.S. Army 4-6 Air Calvary Squadron from Joint Base Luis-McChord in Washington were also involved in the search, officials said.

The cause of the crash is under investigation, according to the statement.

The Growler aircraft, which according to the Navy is worth about $67 million, is “the most advanced technology in airborne Electronic Attack and stands as the Navy’s first line of defense in hostile environments.”

The 130 squadron adopted the nickname “Zappers” when it was commissioned as the Carrier Early Warning Squadron 13 in 1959, the military said.

The squadron was most recently deployed to the Southern Red Sea, where it carried out seven pre-planned strikes against Houthi-controlled areas in Yemen, according to a statement.

The Zappers also carried out some 700 combat missions ” to degrade the Houthi capability to threaten innocent shipping,” according to a press release announcing the squadron’s return to Washington in July.

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Amid ongoing Helene recovery, early voting set to begin in North Carolina

Amid ongoing Helene recovery, early voting set to begin in North Carolina
Amid ongoing Helene recovery, early voting set to begin in North Carolina
adamkaz/Getty Images

(RALEIGH, N.C.) — As North Carolinians continue to recover from the devastating impacts of Hurricane Helene, early voting begins Thursday in the critical swing state.

State election officials expect a majority of North Carolina voters to cast their ballot in-person over the next two weeks, with early voting concluding on Nov. 2.

More than 400 early voting sites are in operation across the state’s 100 counties.

“To have almost all early voting sites open after such a devastating storm is an effort all North Carolinians should be proud of,” North Carolina State Board of Elections executive director Karen Brinson Bell said Tuesday.

Former President Donald Trump and Vice President Kamala Harris remain neck-and-neck in the critical swing state, with Trump holding a 0.4% lead over Harris in 538’s polling average for the state.

Both candidates have visited North Carolina since the remnants of Hurricane Helene brought deadly floods to the state, where 95 people died and 92 remain missing. Trump has repeatedly made false claims about the federal response to the disaster, claiming that the state would be deprived of emergency aid from the Federal Emergency Management Agency because of undocumented immigrants.

“They got hit with a very bad hurricane, especially North Carolina and parts of Georgia. But North Carolina really got hit. I’ll tell you what, those people should never vote for a Democrat, because they held back aid,” Trump said during an interview last week.

While visiting a church in Greenville, North Carolina, on Sunday, Harris stopped short of naming Trump while criticizing the spread of disinformation about the relief efforts in the state.

“Right now, fellow Americans are experiencing some of the most difficult moments in their lives,” Harris said. “Yet instead of offering hope, there are those who are channeling people’s tragedies and sorrows into grievance and hatred, and one may ask why, and I think, sadly, frankly, the motives are quite transparent: to gain some advantage for themselves, to play politics with other people’s heartbreak.”

With recovery efforts ongoing, election officials have expressed optimism about the state’s early voting plans. In the 25 western counties included in the federal disaster declaration, 76 early voting sites have been confirmed — four fewer than originally planned.

“We lost just a few despite the extensive damage, loss of power, water, internet and phone service, and the washing out of roads throughout the region,” said Brinson Bell.

In past presidential elections, the majority of the state’s voters have cast their ballot during early in-person voting, with 65% using that method in 2020 and 62% in 2016. Election officials expect a similar portion of voters to vote early in person, and have enacted a series of measures to improve voting access in the counties hardest hit by Helene.

Voters in the impacted counties can drop off their absentee ballot at any early voting site throughout the state, and the state plans to deploy “multipartisan assistance teams” that can assist with absentee voting at disaster shelters.

This will also be the first presidential election where voters will need to provide photo identification to vote, after lawsuits delayed implementation of the state’s controversial voter ID law following its passage in 2018. Voters can provide a drivers’ license, student ID, or passport to vote, though exceptions are permitted in the case of natural disasters.

The only county to offer fewer early voting sites is hard-hit Buncombe County, whose officials opted to reduce their number of sites from 14 to 10 because of the ongoing emergency response.

“Our office has been preparing for the 2024 election for years, but we certainly didn’t expect this,” said Buncombe County director of election services Corinne Duncan.

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Georgia judge invalidates more controversial election rules

Georgia judge invalidates more controversial election rules
Georgia judge invalidates more controversial election rules
seng kui Lim / 500px/Getty Images

(GEORGIA) — One day after a Georgia judge invalidated the state’s controversial “hand count” rule, a separate judge Wednesday evening invalidated even more rules that were passed by the Republican-led state election board, declaring them “unlawful and void.”

Fulton County Judge Thomas Cox ruled after an hours-long hearing to invalidate seven rules total, including the hand count rule, finding in part that the board did not have the authority to enact them.

Cox made clear that the State of Georgia and the State Election Board “are hereby DIRECTED TO IMMEDIATELY REMOVE THESE RULES FROM THEIR ROLES AND OFFICIAL REPORTING” and to “IMMEDIATELY INFORM ALL STATE AND LOCAL ELECTION OFFICIALS THAT THESE RULES ARE VOID AND ARE NOT TO BE FOLLOWED,” in his decision.

The rules now invalidated include a rule calling county officials to certify election results after “reasonable inquiry.”

Cox wrote in his order that rule “adds an additional and undefined step into the certification process” and that it is “inconsistent with and unsupported” by state law.

He also invalidated a rule that “requires that a person delivering an absentee ballot provide a signature and photo ID at the time the absentee ballot is delivered.”

The judge said in his ruling that state provisions don’t require that.

“The SEB thus has no authority to require such presentment as a condition of accepting and counting an otherwise properly delivered ballot,” Cox wrote.

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Vance says ‘no’ Trump didn’t lose the 2020 election

Vance says ‘no’ Trump didn’t lose the 2020 election
Vance says ‘no’ Trump didn’t lose the 2020 election
Meg Oliphant / Stringer/Getty Images

(Williamsport, Pennsylvania) — In his most direct answer yet of this election cycle, GOP vice presidential nominee Sen. JD Vance said he does not believe former President Donald Trump lost the 2020 election.

Vance’s response occurred when a reporter asked, “What message do you think it sends to Independent voters when you do not directly answer the question, ‘Did Donald Trump lose in 2020?'”

“On the election of 2020, I’ve answered this question directly a million times. No, I think there are serious problems in 2020 so did Donald Trump lose the election? Not by the words that I would use,” Vance said.

“But look, I really couldn’t care less if you agree or disagree with me on this issue.”

In a recently resurfaced clip from Spectrum News 1 in 2022, Vance said, “Yeah, I do,” when asked if he believed the 2020 election was stolen.

President Joe Biden defeated former President Donald Trump in the 2020 election by more than 7 million votes.

Vance’s response comes after weeks of being asked by reporters if the former president lost the 2020 election.

This past Sunday in his interview with ABC’s Martha Raddatz, Vance continued to dodge directly answering if Trump lost the 2020 election.

“Martha, you’ve you asked this question. I’ve been asked this question 10 times in the past couple of weeks. Of course, Donald Trump and I believe there were problems in 2020,” Vance said.

Pressed again by Raddatz, Vance replied, “I’ve said repeatedly I think the 2020 election had problems. You want to say rigged? You want to say he won? Use whatever vocabulary term you want.”

Taking questions from reporters at a campaign event in Williamsport, Pennsylvania, ABC News asked the Ohio Senator if he was concerned about election misinformation could impact this election cycle, Vance said he was concerned.

“I talk to people every now and then who will come up to me and say, ‘Well, you know, there are too many problems out there. We don’t trust the people who are going to count our ballots, and you know, so I’m not going to get out there and vote.’ That’s the exact opposite attitude you should be taking,” Vance said.

Trying to ease those who might have doubts about the election, Vance said that those who will be working the polls on election day are the same people in their community.

“Here’s something else that I think people don’t realize is, if you’re a local voter in a place like Williamsport, the people who are counting your ballots are often your neighbors. And again, it’s the local elections, and especially in our small and rural areas, it’s your neighbors who are counting these votes, it’s your neighbors who are counting these ballots.”

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Georgia sees 2nd day of record early voting turnout

Georgia sees 2nd day of record early voting turnout
Georgia sees 2nd day of record early voting turnout
SimpleImages/Getty Images

(GEORGIA) — Gabriel Sterling, the Chief Operations Officer of Georgia’s office of Secretary of State, noted in a statement on X that early votes cast Wednesday set a record for a second day.

“So, with the rest of today and absentees we could get close to 600,000 votes cast in Georgia. We continue on the record-setting pace and we are thankful for our election workers at the counties and our voters,” he said.

On the previous day, 312,206 people cast an early vote, shattering the 136,000 votes cast in the first day of early voting in 2002, according to state election data.

Sterling said earlier in the day that the 500,000 votes cast mark represented 10% of the turnout in the 2020 election.

As of Wednesday night, 33,359 absentee ballots have been returned and 33,150 of those ballots were accepted, according to the secretary of state’s office.

Georgia is seen as a crucial swing state for the presidential race, with both former President Donald Trump and Vice President Kamala Harris have been actively campaigning throughout neighborhoods in the state.

Voting rights advocates have been pushing voters to choose the early voting option due to concerns about new rules including one that makes it harder to cast a provisional ballot on Election Day if a voter is sent to the wrong polling place. Georgia voters can choose any early voting election site in their county, according to state law.

Early voting in Georgia will continue until Nov. 1.

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Mississippi bridge collapses in deadly accident at demolition site: Officials

Mississippi bridge collapses in deadly accident at demolition site: Officials
Mississippi bridge collapses in deadly accident at demolition site: Officials
Royalty-free/Getty Images

(SIMPSON COUNTY, Miss.) — A Mississippi bridge set to be demolished collapsed in a deadly accident on Wednesday, officials said.

The Mississippi Department of Transportation confirmed there were fatalities, though it did not specify how many people died.

“[We] extend our deepest condolences to the families who have lost loved ones,” the Mississippi Department of Transportation said in a statement.

An inspector with the Mississippi Department of Transportation who was at the worksite when the bridge collapsed was unharmed, the department said.

The bridge, which spanned the Strong River in Simpson County on State Route 149, collapsed Wednesday afternoon, according to the Mississippi Department of Transportation.

The bridge had been closed to traffic since Sept. 18 and was in the process of being demolished as part of a bridge replacement project, the department said.

The replacement project had been given an estimate of 12 to 18 months to complete, according to previous statements from the department.

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Harris paints Trump as threat, draws contrast with Biden in combative Fox News interview

Harris paints Trump as threat, draws contrast with Biden in combative Fox News interview
Harris paints Trump as threat, draws contrast with Biden in combative Fox News interview
Brandon Bell / Staff/Getty Images

(NEW YORK) — Vice President Kamala Harris on Wednesday hammered former President Donald Trump as thin-skinned and a threat to U.S. democracy in a combative interview with Fox News.

The interview marked an opportunity for Harris to appear on a network that frequently criticizes her and praises her opponent, a notable moment after Republicans had panned her for only granting interviews with friendly reporters or podcasters. True to form, the interview was testy throughout, including multiple exchanges in which Harris and Fox News anchor Bret Baier repeatedly spoke over each other.

Harris raised Trump’s recent rhetoric about the “enemy within” and threats to use the military to go after political opponents on and supposed chaos on Election Day to suggest that he’s unfit for a second term in office, adding that it is “clear to me” that Trump is “unfit to serve, that he is unstable, that he is dangerous.”

“You and I both know that he has talked about turning the American military on the American people. He has talked about going after people who are engaged in peaceful protest. He has talked about locking people up because they disagree with him,” Harris told Fox News anchor Bret Baier.

“This is a democracy, and in a democracy the president of the United States in the United States of America, should be willing to be able to handle criticism without saying he’d lock people up for doing it,” she said.

The remarks mark an escalation of her rhetoric describing Trump as dangerous for the country as he escalates his rhetoric about internal threats from Americans, including “radical left lunatics,” raising concerns about how he’d use the military in a future administration.

‘Not a continuation of Joe Biden’s presidency’: Harris
Harris also attempted to flesh out the differences Americans would see between President Joe Biden’s administration and her theoretical term in the White House, offering several examples after Republicans seized on her answer on ABC’s “The View” last week that “not a thing that comes to mind” when asked what she would have done something differently from Biden over the past four years.

“You’re not Joe Biden, you’re not Donald Trump, but, but nothing comes to mind that you would do differently?” Baier asked.

“My presidency will not be a continuation of Joe Biden’s presidency, and like every new president that comes into office, I will bring my life experiences, my professional experiences, and fresh and new ideas,” she told Baier.

Harris specifically raised her plans to offer increased housing assistance to first-time home buyers and provide funds to start small businesses.

Still, she added that her administration would mark a turning of the page from what she called the divisiveness of the Trump era in U.S. politics.

Redirecting Her election would mark a change “from the last decade in which we have been burdened with the kind of rhetoric coming from Donald Trump that has been designed and implemented to divide our country and have Americans literally point fingers at each other,” she said.

Pressed on immigration
Baier also pressed Harris on immigration and high levels of border crossings for much of the Biden administration.

Harris did not directly respond to a question about how many undocumented immigrants were released into the country, instead panning Trump for opposing a bipartisan plan that would have beefed up border security. She did, however, express sympathy for families who had loved ones killed by those who crossed the border illegally.

“Those are tragic cases. There’s no question about that. There is no question about that, and I can’t imagine the pain that the families of those victims have experienced for a loss that should not have occurred,” Harris said.

“So that is true. It is also true that if border security had actually been passed nine months ago, it would be nine months that we would have had more border agents at the border, more support for the folks who are working around the clock trying to hold it all together to ensure that no future harm would occur.”

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